Over 3,700 care home staff left their jobs during the week that mandatory vaccination came into effect, NHS figures have revealed.
NHS England data showed than 3,743 workers left their posts in the seven days ending 14 November.
The data is the first to be released including the 11 November mandatory jab deadline.
The PA newsagency reported there were 7,806 fewer staff in care homes in England since the deadline for staff to receive their first jab in September.
Following the week ending 19 September, 5,603 staff in care homes for older people and 2,203 staff in care homes for younger people had left their roles.
Almost half of people leaving since mid-September (48%) occurred in the week up to 14 November.
Of these, 3,162 were in care homes for older people and 581 were in care homes for young adults.
Almost 43,000 staff in care homes were not fully vaccinated as of the deadline.
Around 7.5% of staff (34,291 people) were not fully vaccinated in care homes for older people and 10% of staff (8,609) in care homes for younger adults.
Several thousand of these are believed to have self-certified as medically exempt or to have applied for formal proof.
The local authorities with the highest level of unvaccinated people include West Northamptonshire (14.9%), Thurrock (13.8%) and Westminster (13.0%).
A Department of Health and Social Care spokesperson said: “As the Health and Social Care Secretary said, NHS and care staff do amazing work and we are thankful to those who have chosen to get the vaccine.
“This is about patient safety – we know vaccines work and if those in hospital and care are exposed to COVID-19 it could be fatal. It’s our duty to ensure that they are as safe as can be.”