Deaths of people in care homes with COVID-19 symptoms hit a four-month high at the end of October, according to the ONS.
In its latest weekly release, the ONS said there were 168 COVID-19 related deaths in care homes in England and Wales in the week ending 30 October, the highest level since the beginning of July.
On a year to date basis, there were 16,140 deaths in care homes in England and Wales.
Deaths involving COVID-19 in care homes as a proportion of all deaths in care homes increased to 7.9% from 7.1% in the previous week.
CQC data revealed there were 15,318 deaths of residents in care homes involving COVID-19 in England from 10 April to 6 November, with 299 notified in the week up to 6 November.
In Wales, Care Inspectorate Wales reported 763 deaths of residents involving COVID-19 between 1 March and 23 October.
The news came as further coronavirus outbreaks were reported this week in care homes around the country.
Leading care home operator, HC-One, confirmed 11 positive cases amongst residents who are isolated on one floor of its Mavisbank care home in Bishopsbriggs near Glasgow. There were 15 positive cases amongst asymptomatic staff members that were picked up during routine testing.
HC-One also confirmed that less than five residents had sadly passed away at the home.
Not for profit provider, MHA, meanwhile, confirmed that incident management arrangements had been introduced after a number of residents tested positive at its Hafan y Waun Care Home in Aberystwyth, Wales.